Cellular barcoding and other single-cell lineage-tracing strategies form experimental methodologies for analysis of in vivo cell fate that have been instrumental in several significant recent discoveries.Due to the highly nonlinear nature of proliferation and differentiation, interrogation of the resulting data Chafer Fuel for evaluation of potenti
Abstract Background Hibernation in an appropriate environment not only is important for the survival of hibernators in winter, but also is crucial for breeding in the following season for many hibernating species.However, the genetic and epigenetic mechanism underlying this process remain unclear.In the current study, we performed an integrative mu
The strength of the stratospheric wave driving during northern winter is often quantified by the January–February mean poleward eddy heat flux at 100 hPa, averaged over 40°–80° N (or a similar area and period).Despite the dynamical and chemical relevance of the wave driving, the causes for its variability are still not well unde
Sustainable development in coal mining requires a continuous and efficient method of coal extraction.Research shows that gob-side entries retained through roof cutting retained gob-side (RCGE) are vital for improving mining efficiency, enhancing coal recovery rates, and enabling continuous production.However, the mechanism of surrounding rock defor
Introduction2021 Global Initiative for Chronic Obstructive Lung Disease (GOLD) Reports recommends that patients with clinically significant symptoms and exacerbations of chronic obstructive pulmonary disease (COPD) should escalate to triple therapy, a combined use of inhaled corticosteroids (ICS), long-acting muscarinic antagonists (LAMA) and long-